Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory

Affiliations

Nick Holford. AAPS J. 2011 Dec.

. 2011 Dec;13(4):662-4.

doi: 10.1208/s12248-011-9306-5. Epub 2011 Oct 18.

¹ Clinical Pharmacology, University of Auckland, New Zealand. n.holford@auckland.ac.nz

No abstract available

Figures

Pharmacodynamics of methylprednisolone phosphate after single intravenous administration to healthy volunteers.
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Influence of input rates on (+/-)-isradipine haemodynamics and concentration-effect relationship in healthy volunteers.
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Verapamil disposition and cardiovascular effects in elderly patients after single intravenous and oral doses.
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