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. 2011 Dec;13(4):662-4.
doi: 10.1208/s12248-011-9306-5. Epub 2011 Oct 18.

Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory

Nick Holford  1
Affiliations

Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory

Nick Holford. AAPS J. 2011 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
Acetyl choline concentration–effect relationship. Contractions of a segment of guinea pig ileum suspended in oxygenated warm Krebs solution are recorded after addition of known doses of acetyl choline to a fixed volume so that the concentration could be calculated. Contractions were recorded by a mechanical lever system which scraped charcoal from the surface of a smoked rotating drum
See this image and copyright information in PMC

References

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    1. Whiting B, Holford NH, Sheiner LB. Quantitative analysis of the disopyramide concentration-effect relationship. Br J Clin Pharmacol. 1980;9(1):67–75. - PMC - PubMed
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    1. Holford NH, Sheiner LB. Kinetics of pharmacologic response. Pharmacol Ther. 1982;16(2):143–166. doi: 10.1016/0163-7258(82)90051-1. - DOI - PubMed

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