Phosphoinositide 3'-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia
- PMID: 22006556
- PMCID: PMC3248155
- DOI: 10.18632/oncotarget.341
Phosphoinositide 3'-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia
Abstract
PI3K signaling is now targeted in first clinical trials in patients with B cell malignancies, including Chronic Lymphocytic Leukemia (CLL), which represent one of the first molecularly targeted therapies for B cell malignancies.
Comment on
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Refractory chronic lymphocytic leukemia--new therapeutic strategies.Oncotarget. 2010 Nov;1(7):472-482. doi: 10.18632/oncotarget.184. Oncotarget. 2010. PMID: 21317446 Free PMC article. Review.
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Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia.Oncotarget. 2010 Nov;1(7):578-582. doi: 10.18632/oncotarget.192. Oncotarget. 2010. PMID: 21317453 Free PMC article. Review.
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