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Multicenter Study
. 2011 Dec;86(12):998-1000.
doi: 10.1002/ajh.22168. Epub 2011 Oct 17.

Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma

Carrie A Thompson  1 , Matthew J Maurer, James R Cerhan, Jerry A Katzmann, Stephen M Ansell, Thomas M Habermann, William R Macon, George J Weiner, Brian K Link, Thomas E Witzig
Affiliations
Multicenter Study

Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma

Carrie A Thompson et al. Am J Hematol. 2011 Dec.

Abstract

The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. We analyzed the association of pretreatment FLC with event-free survival (EFS) and overall survival (OS) in 100 patients with Hodgkin lymphoma (HL). Elevated polyclonal FLC were present in 30% of patients; these patients had an inferior EFS (HR = 4.84; 95% CI: 1.84-12.7) and OS (HR = 8.87; 95% CI: 2.35-33.52) compared to patients with normal FLC. Further studies of FLC in HL are warranted.

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Conflict of interest statement

Conflict of interest: Nothing to report

Figures

Figure 1
Figure 1
Kaplan Meier curves for event-free (A) and overall survival (B). Hazard ratios are unadjusted Cox models and Cox model adjusted for International Prognostic Score. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
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