Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Oct 18;155(8):529-36.
doi: 10.7326/0003-4819-155-8-201110180-00009.

QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

Penny F Whiting  1 , Anne W S Rutjes, Marie E Westwood, Susan Mallett, Jonathan J Deeks, Johannes B Reitsma, Mariska M G Leeflang, Jonathan A C Sterne, Patrick M M Bossuyt; QUADAS-2 Group
Collaborators, Affiliations
Free article

QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

Penny F Whiting et al. Ann Intern Med. .
Free article

Abstract

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

PubMed Disclaimer

Comment in

  • The revised QUADAS-2 tool.
    Schueler S, Schuetz GM, Dewey M. Schueler S, et al. Ann Intern Med. 2012 Feb 21;156(4):323; author reply 323-4. doi: 10.7326/0003-4819-156-4-201202210-00018. Ann Intern Med. 2012. PMID: 22351721 No abstract available.

Publication types