Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct 18;124(16):1783-91.
doi: 10.1161/CIRCULATIONAHA.110.006767.

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update

Nalini M Rajamannan  1 , Frank J Evans, Elena Aikawa, K Jane Grande-Allen, Linda L Demer, Donald D Heistad, Craig A Simmons, Kristyn S Masters, Patrick Mathieu, Kevin D O'Brien, Frederick J Schoen, Dwight A Towler, Ajit P Yoganathan, Catherine M Otto
Affiliations
Review

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update

Nalini M Rajamannan et al. Circulation. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Echocardiographic and Bioengineering and Hemodynamic Force Perspective of the diastole and systole in the aortic root affecting aortic valve leaflet cell and function Panel A. Panel B, demonstrates the cellular architecture of a normal aortic valve. Panel C, demonstrates the osteogenic phenotype of the calcified aortic valve.
Figure 2
Figure 2
Potential roles of Lipoprotein retention and signaling, oxidative stress, and reninangiotensin system activation in the pathogenesis of calcific aortic valve disease.
Figure 3
Figure 3
The identified atherosclerotic cardiovascular risk factors involved in the development of aortic valve disease from sclerosis to calcific aortic valve disease
See this image and copyright information in PMC

References

    1. Schoen FJ. Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering. Circulation. 2008;118:1864–1880. - PubMed
    1. Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2. Circulation research. 2006;99:861–869. - PMC - PubMed
    1. Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. The American journal of pathology. 2009;174:1109–1119. - PMC - PubMed
    1. Blevins TL, Carroll JL, Raza AM, Grande-Allen KJ. Phenotypic characterization of isolated valvular interstitial cell subpopulations. The Journal of heart valve disease. 2006;15:815–822. - PubMed
    1. Rajamannan NM, Nealis TB, Subramaniam M, Pandya S, Stock SR, Ignatiev CI, Sebo TJ, Rosengart TK, Edwards WD, McCarthy PM, Bonow RO, Spelsberg TC. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation. Circulation. 2005;111:3296–3301. - PMC - PubMed

Publication types