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Review
. 2011:2011:567305.
doi: 10.1155/2011/567305. Epub 2011 Oct 11.

E-cadherin/β-catenin complex and the epithelial barrier

Xinrui Tian  1 , Zhuola Liu, Bo Niu, Jianlin Zhang, Thian Kui Tan, So Ra Lee, Ye Zhao, David C H Harris, Guoping Zheng
Affiliations
Review

E-cadherin/β-catenin complex and the epithelial barrier

Xinrui Tian et al. J Biomed Biotechnol. 2011.

Abstract

E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.

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Figures

Figure 1
Figure 1
E-cadherin/β-catenin complex in epithelial cell-cell adhesion and Wnt signalling.
See this image and copyright information in PMC

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