doi: 10.1155/2012/268123.
Epub 2011 Oct 5.
Histoplasma virulence and host responses
Affiliations
- PMID: 22007223
- PMCID: PMC3189557
- DOI: 10.1155/2012/268123
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Histoplasma virulence and host responses
Int J Microbiol.
2012.
Abstract
Histoplasma capsulatum is the most prevalent cause of fungal respiratory disease. The disease extent and outcomes are the result of the complex interaction between the pathogen and a host's immune system. The focus of our paper consists in presenting the current knowledge regarding the multiple facets of the dynamic host-pathogen relationship in the context of the virulence arsenal displayed by the fungus and the innate and adaptive immune responses of the host.
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References
-
- Wheat LJ, Kauffman CA. Histoplasmosis. Infectious Disease Clinics of North America. 2003;17(1):1–19. - PubMed
-
- Goodwin RA, Loyd JE, Des Prez RM. Histoplasmosis in normal hosts. Medicine. 1981;60(4):231–266. - PubMed
-
- Deepe GS., Jr. The immune response to Histoplasma capsulatum: unearthing its secrets. Journal of Laboratory and Clinical Medicine. 1994;123(2):201–205. - PubMed
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