Serum aldosterone is associated with inflammation and aortic stiffness in normotensive overweight and obese young adults

Abstract

Circulating aldosterone is increased in obesity and is associated with arterial stiffening in hypertensives and older adults. The aim of this article was to determine whether serum aldosterone is associated with pulse wave velocity (PWV), a measure of arterial stiffness, in normotensive overweight and obese adults aged 20-45 years (n = 344). Heart-femoral, femoral-ankle, and brachial-ankle PWV were measured. The sample was 77% female with mean body mass index 32.9 kg/m(2) (SD 3.9), median serum aldosterone 106.5 pg/mL (interquartile range 79.9, 155.5), and mean 24-hour urinary sodium excretion 185.9 mEq/day (SD 69.6). Higher serum aldosterone was not significantly correlated with any PWV measure in bivariate analysis. However, in multiple linear regression, adjusting for age, sex, race, height, heart rate, mean arterial pressure, and waist circumference, higher log aldosterone was associated with greater log heart-femoral PWV (β(se) = 0.042(0.021), P = .049). After adjusting for C-reactive protein, this association was no longer significant (β(se) = 0.035(0.021), P = .10). Circulating aldosterone may play an important role in vascular inflammation and aortic stiffening in normotensive overweight and obese adults.

Trial registration: ClinicalTrials.gov NCT00366990.

Figure 1

Association between log heart-femoral pulse wave velocity (hfPWV) in cm/s and log aldosterone in pg/mL when adjusted for age, sex, race (black/non-black), height, heart rate, waist circumference, and mean arterial pressure.