Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Oct 18:7:45.
doi: 10.1186/1744-9081-7-45.

Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating

Peg Nopoulos  1 , Eric A Epping, Tom Wassink, Bradley L Schlaggar, Joel Perlmutter
Affiliations

Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating

Peg Nopoulos et al. Behav Brain Funct. .

Abstract

Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Relationship between CAG repeat length of Allele1 and CAG repeat length of Allele2.
See this image and copyright information in PMC

References

    1. Richards RI, Sutherland GR. Dynamic mutations: a new class of mutations causing human disease. Cell. 1992;70(5):709–12. doi: 10.1016/0092-8674(92)90302-S. - DOI - PubMed
    1. Fondon JW, Garner HR. Molecular origins of rapid and continuous morphological evolution. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(52):18058–63. doi: 10.1073/pnas.0408118101. - DOI - PMC - PubMed
    1. Fondon JW. et al.Simple sequence repeats: genetic modulators of brain function and behavior. Trends in neurosciences. 2008;31(7):328–34. doi: 10.1016/j.tins.2008.03.006. - DOI - PubMed
    1. Hannan AJ. Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for 'missing heritability'. Trends in genetics: TIG. 2010;26(2):59–65. doi: 10.1016/j.tig.2009.11.008. - DOI - PubMed
    1. Hannan AJ. TRPing up the genome: Tandem repeat polymorphisms as dynamic sources of genetic variability in health and disease. Discovery medicine. 2010;10(53):314–21. - PubMed

Publication types