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Randomized Controlled Trial
. 2012 Jan;56(1):52-9.
doi: 10.1007/s10384-011-0095-2. Epub 2011 Oct 19.

Multicenter randomized clinical trial of retinal photocoagulation for preproliferative diabetic retinopathy

Japanese Society of Ophthalmic Diabetology, Subcommittee on the Study of Diabetic Retinopathy Treatment; Yukihiro Sato, Noriko Kojimahara, Shigehiko Kitano, Satoshi Kato, Noburo Ando, Naohito Yamaguchi, Sadao Hori
Randomized Controlled Trial

Multicenter randomized clinical trial of retinal photocoagulation for preproliferative diabetic retinopathy

Japanese Society of Ophthalmic Diabetology, Subcommittee on the Study of Diabetic Retinopathy Treatment et al. Jpn J Ophthalmol. 2012 Jan.

Abstract

Purpose: To evaluate the effectiveness of selective photocoagulation (S-PC) for nonperfusion areas (NPA) in preproliferative diabetic retinopathy (PPDR).

Subjects and methods: A multicenter randomized controlled clinical trial of 69 patients with PPDR showing NPA comparable to or larger than those on reference photographs. The patients were assigned to 2 groups; one was treated with S-PC (PC group: 32 patients), while the other did not receive S-PS (non-PC group: 37 patients). In the non-PC group, panretinal photocoagulation (PRP) was performed whenever proliferative diabetic retinopathy (PDR) developed. In the PC group, S-PC of the NPA was performed followed by additional coagulation whenever the NPA extended, and PRP was performed whenever PDR developed. The primary outcome was the development of PDR.

Results: During the entire course, PDR developed in 18 (26%) of the 69 patients. The incidence was significantly higher in the non-PC group than in the PC group. Comparison of the visual acuity at the time of registration and after 36 months showed no significant differences between the two groups.

Conclusions: S-PC for NPA in PPDR is effective at preventing PDR development.

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