Rheumatoid arthritis: HDAC and HDACi: pathogenetic and mechanistic insights

Comment

Jenny Buckland. Nat Rev Rheumatol. 2011.

. 2011 Oct 18;7(12):682.

doi: 10.1038/nrrheum.2011.162.

No abstract available

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Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients.
Gillespie J, Savic S, Wong C, Hempshall A, Inman M, Emery P, Grigg R, McDermott MF. Gillespie J, et al. Arthritis Rheum. 2012 Feb;64(2):418-22. doi: 10.1002/art.33382. Arthritis Rheum. 2012. PMID: 21952924
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.
Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA. Grabiec AM, et al. Ann Rheum Dis. 2012 Mar;71(3):424-31. doi: 10.1136/ard.2011.154211. Epub 2011 Sep 27. Ann Rheum Dis. 2012. PMID: 21953341 Free PMC article.