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. 2011 Dec 2;7(23):3281-6.
doi: 10.1002/smll.201101836. Epub 2011 Oct 19.

Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Yong Taik Lim  1 , Sang-Mu Shim, Young-Woock Noh, Kyung-Soon Lee, Doo-Yeol Choi, Hiroshi Uyama, Hee Ho Bae, Ji Hyun Kim, Kwan Soo Hong, Moon-Hee Sung, Haryoung Poo
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Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Yong Taik Lim et al. Small. .

Abstract

An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

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