Efficacy, safety, and cost-effectiveness of glatiramer acetate in the treatment of relapsing-remitting multiple sclerosis
- PMID: 22010043
- PMCID: PMC3187678
- DOI: 10.1177/1756285611422108
Efficacy, safety, and cost-effectiveness of glatiramer acetate in the treatment of relapsing-remitting multiple sclerosis
Abstract
The current Multiple Sclerosis (MS) therapeutic landscape is rapidly growing. Glatiramer acetate (GA) remains unique given its non-immunosuppressive mechanism of action as well as its superior long-term safety and sustained efficacy data. In this review, we discuss proposed mechanisms of action of GA. Then we review efficacy data for reduction of relapses and slowing disability as well as long term safety data. Finally we discuss possible future directions of this unique polymer in the treatment of MS.
Keywords: copaxone®; disease modifying therapies; glatiramer acetate; multiple sclerosis.
References
-
- Abramsky O., Teitelbaum D., Arnon R. (1977) Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomeylitis. Preliminary report. J Neurol Sci 31: 433–438 - PubMed
-
- Azoulay D., Vachapova V., Shihman B., Miler A., Karni A. (2005) Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate. J Neuroimmunol 167: 215–218 - PubMed
LinkOut - more resources
Full Text Sources
