A dynamic view of mHLA-DR expression in management of severe septic patients

doi:10.1186/cc10452

Comment

. 2011;15(5):198.

doi: 10.1186/cc10452. Epub 2011 Oct 17.

A dynamic view of mHLA-DR expression in management of severe septic patients

Guillaume Monneret¹, Alain Lepape, Fabienne Venet

Affiliations

PMID: 22011628
PMCID: PMC3334761
DOI: 10.1186/cc10452

Comment

A dynamic view of mHLA-DR expression in management of severe septic patients

Guillaume Monneret et al. Crit Care. 2011.

. 2011;15(5):198.

doi: 10.1186/cc10452. Epub 2011 Oct 17.

Authors

Guillaume Monneret¹, Alain Lepape, Fabienne Venet

Affiliation

¹ Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 place d'Arsonval, 69437 Lyon cedex 03, France. guillaume.monneret@chu-lyon.fr

PMID: 22011628
PMCID: PMC3334761
DOI: 10.1186/cc10452

Abstract

Increasing evidence suggests that the secondary phase of sepsis (that is, after the first proinflammatory hours) is characterized by the occurrence of a systemic failure of the immune system. In the most immunodepressed patients, therapies could be used to restore normal immune functions. However, biomarkers need to be developed to beforehand specifically identify these patients. Of these biomarkers, diminished monocyte HLA-DR expression has rapidly become the most popular. Herein, novel perspectives regarding monocyte HLA-DR assessed as a dynamic parameter in septic patients will be discussed in the context of a recently published study investigating daily evolution of monocyte HLA-DR with regard to 28 day-mortality after severe sepsis.

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Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis.
Wu JF, Ma J, Chen J, Ou-Yang B, Chen MY, Li LF, Liu YJ, Lin AH, Guan XD. Wu JF, et al. Crit Care. 2011;15(5):R220. doi: 10.1186/cc10457. Epub 2011 Sep 20. Crit Care. 2011. PMID: 21933399 Free PMC article.

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References

1. Wu J-F, Jie Ma JC, Ou-Yang B, Chen M-Y, Li LF, Liu Y-J, Lin A-h, Guan X-D. Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis. Crit Care. 2011;15:R220. doi: 10.1186/cc10457. - DOI - PMC - PubMed
1. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138–150. doi: 10.1056/NEJMra021333. - DOI - PubMed
1. Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med. 2008;14:64–78. - PMC - PubMed
1. Monneret G, Venet F, Kullberg BJ, Netea MG. ICU-acquired immunosuppression and the risk for secondary fungal infections. Med Mycol. 2011;49(Suppl 1):S17–S23. - PubMed
1. Kalil AC, Florescu DF. Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med. 2009;37:2350–2358. doi: 10.1097/CCM.0b013e3181a3aa43. - DOI - PubMed

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[1] Wu J-F, Jie Ma JC, Ou-Yang B, Chen M-Y, Li LF, Liu Y-J, Lin A-h, Guan X-D. Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis. Crit Care. 2011;15:R220. doi: 10.1186/cc10457. - DOI - PMC - PubMed

[2] Wu J-F, Jie Ma JC, Ou-Yang B, Chen M-Y, Li LF, Liu Y-J, Lin A-h, Guan X-D. Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis. Crit Care. 2011;15:R220. doi: 10.1186/cc10457. - DOI - PMC - PubMed

[3] Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138–150. doi: 10.1056/NEJMra021333. - DOI - PubMed

[4] Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138–150. doi: 10.1056/NEJMra021333. - DOI - PubMed

[5] Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med. 2008;14:64–78. - PMC - PubMed

[6] Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med. 2008;14:64–78. - PMC - PubMed

[7] Monneret G, Venet F, Kullberg BJ, Netea MG. ICU-acquired immunosuppression and the risk for secondary fungal infections. Med Mycol. 2011;49(Suppl 1):S17–S23. - PubMed

[8] Monneret G, Venet F, Kullberg BJ, Netea MG. ICU-acquired immunosuppression and the risk for secondary fungal infections. Med Mycol. 2011;49(Suppl 1):S17–S23. - PubMed

[9] Kalil AC, Florescu DF. Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med. 2009;37:2350–2358. doi: 10.1097/CCM.0b013e3181a3aa43. - DOI - PubMed

[10] Kalil AC, Florescu DF. Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med. 2009;37:2350–2358. doi: 10.1097/CCM.0b013e3181a3aa43. - DOI - PubMed

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A dynamic view of mHLA-DR expression in management of severe septic patients

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A dynamic view of mHLA-DR expression in management of severe septic patients

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