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. 2011 Dec 7;9(23):8000-2.
doi: 10.1039/c1ob06619f. Epub 2011 Oct 20.

Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: formal synthesis of (±)-grandisol

Donald Craig  1 , Kiyohiko Funai, Sophie J Gore, Albert Kang, Alexander V W Mayweg
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Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: formal synthesis of (±)-grandisol

Donald Craig et al. Org Biomol Chem. .

Abstract

Unsaturated eight-membered lactones undergo decarboxylative and non-decarboxylative transannular Ireland-Claisen rearrangement reactions, to give substituted vinylcyclobutanes. A formal synthesis of (±)-grandisol is described.

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