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Review
. 2011 Nov;31(11):2397-401.
doi: 10.1161/ATVBAHA.108.179556.

History of discovery: platelet-derived growth factor

Daniel F Bowen-Pope  1 , Elaine W Raines
Affiliations
Review

History of discovery: platelet-derived growth factor

Daniel F Bowen-Pope et al. Arterioscler Thromb Vasc Biol. 2011 Nov.

Abstract

A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the different challenges we faced 3 decades ago in this undertaking and describes how our path was influenced by our focus on a disease process and by the evolving general understanding of the molecular effectors of cell proliferation.

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