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Comparative Study
. 2011;66(10):1787-92.
doi: 10.1590/s1807-593220110007000018.

Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia

Marco Antonio Batista  1 , Tomaz Puga Leivas, Consuelo Junqueira Rodrigues, Géssica Cantadori Funes Arenas, Donizeti Rodrigues Belitardo, Roberto Guarniero
Affiliations
Comparative Study

Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia

Marco Antonio Batista et al. Clinics (Sao Paulo). 2011.

Abstract

Objective: To perform a comparative analysis of the effects of platelet-rich plasma and centrifuged bone marrow aspirate on the induction of bone healing in rabbits.

Method: Twenty adult, male New Zealand rabbits were randomly separated into two equal groups, and surgery was performed to create a bone defect (a cortical orifice 3.3 mm in diameter) in the proximal metaphysis of each rabbit's right tibia. In the first group, platelet-rich plasma was implanted in combination with β-tricalcium phosphate (platelet-rich plasma group), and in the second group, centrifuged bone marrow in combination with β-tricalcium phosphate (centrifuged bone marrow group) was implanted. After a period of four weeks, the animals were euthanized, and the tibias were evaluated using digital radiography, computed tomography, and histomorphometry.

Results: Seven samples from each group were evaluated. The radiographic evaluation confirmed the absence of fractures in the postoperative limb and identified whether bone consolidation had occurred. The tomographic evaluation revealed a greater amount of consolidation and the formation of a greater cortical bone thickness in the platelet-rich plasma group. The histomorphometry revealed a greater bone density in the platelet-rich plasma group compared with the centrifuged bone marrow group.

Conclusion: After four weeks, the platelet-rich plasma promoted a greater amount of bone consolidation than the bone marrow aspirate concentrate.

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Conflict of interest statement

No potential conflict of interest was reported.

Figures

Figure 1
Figure 1
Bone defect obtained after drilling in the right tibia (a) and after implantation of the βTCP and PRP cylinder (b).
Figure 2
Figure 2
Axial CT image of the tibia of an animal in the PRP group showing the consolidation of newly formed bone defect and a cortical thickness of 1.3 mm (a) and the BMC group showing no consolidation of the cortical bone defect (b).
Figure 3
Figure 3
Photomicrographs of bone defect consolidation in an animal in the PRP group (a) and the BMC group (b).
See this image and copyright information in PMC

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