Hedgehog rushes to the rescue of the developing cerebellum
- PMID: 22013122
- DOI: 10.1126/scitranslmed.3003080
Hedgehog rushes to the rescue of the developing cerebellum
Abstract
Premature birth often is associated with neurodevelopmental disabilities. In this issue of Science Translational Medicine, a pair of papers investigate--in patients and in a reliable animal model--the effects of glucocorticoids on cerebellar development after premature birth.
Comment on
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A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury.Sci Transl Med. 2011 Oct 19;3(105):105ra104. doi: 10.1126/scitranslmed.3002731. Sci Transl Med. 2011. PMID: 22013124 Free PMC article.
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Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids.Sci Transl Med. 2011 Oct 19;3(105):105ra105. doi: 10.1126/scitranslmed.3002884. Sci Transl Med. 2011. PMID: 22013125 Free PMC article.
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