Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct;26(5):314-25.
doi: 10.1152/physiol.00020.2011.

Why is chromosome segregation error in oocytes increased with maternal aging?

Zhen-Bo Wang  1 , Heide Schatten, Qing-Yuan Sun
Affiliations
Free article
Review

Why is chromosome segregation error in oocytes increased with maternal aging?

Zhen-Bo Wang et al. Physiology (Bethesda). 2011 Oct.
Free article

Abstract

It is well documented that female fertility is decreased with advanced maternal age due to chromosome abnormality in oocytes. Increased chromosome missegregation is mainly caused by centromeric cohesion reduction. Other factors such as weakened homologous recombination, improper spindle organization, spindle assembly checkpoint (SAC) malfunction, chromatin epigenetic changes, and extra-oocyte factors may also cause chromosome errors.

PubMed Disclaimer

Publication types

LinkOut - more resources