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. 2012:2012:175245.
doi: 10.1155/2012/175245. Epub 2011 Oct 16.

Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome

Tiziana Di Chiara  1 , Christiano Argano, Salvatore Corrao, Rosario Scaglione, Giuseppe Licata
Affiliations

Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome

Tiziana Di Chiara et al. J Nutr Metab. 2012.

Abstract

Metabolic syndrome (MetS) represents a combination of cardiometabolic risk factors, including visceral obesity, glucose intolerance or type 2 diabetes, elevated triglycerides, reduced HDL cholesterol, and hypertension. MetS is rapidly increasing in prevalence worldwide as a consequence of the "epidemic" obesity, with a considerable impact on the global incidence of cardiovascular disease and type 2 diabetes. At present, there is a growing interest on the role of visceral fat accumulation in the occurrence of MetS. In this review, the effects of adipocytokines and other proinflammatory factors produced by fat accumulation on the occurrence of the MetS have been also emphasized. Accordingly, the "hypoadiponectinemia" has been proposed as the most interesting new hypothesis to explain the pathophysiology of MetS.

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Figures

Figure 1
Figure 1
Adverse cardiometabolic effects of products of adipocytes (from Scaglione et al. ([12] modified)).
Figure 2
Figure 2
Progression and outcomes of visceral obesity.
See this image and copyright information in PMC

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