Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:280630.
doi: 10.4061/2011/280630. Epub 2011 Oct 16.

Progression of White Matter Lesion Volume and Health-Related Quality of Life in Patients with Symptomatic Atherosclerotic Disease: The SMART-MR Study

Anne M Grool  1 , Yolanda van der Graaf, Theo D Witkamp, Koen L Vincken, Willem P T M Mali, Mirjam I Geerlings
Affiliations

Progression of White Matter Lesion Volume and Health-Related Quality of Life in Patients with Symptomatic Atherosclerotic Disease: The SMART-MR Study

Anne M Grool et al. J Aging Res. 2011.

Abstract

Objectives. Mechanisms influencing the course of physical and mental functioning after an atherosclerotic event are unclear. We examined effects of white matter lesion (WML) activity on changes in functioning in patients with symptomatic atherosclerotic disease. Methods. In 486 patients (58 ± 9 years) of the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, volumetric WML measurements on 1.5T MRI were performed at baseline and 3.9 ± 0.4 years followup. Functioning was assessed with the modified Short-Form 12 (SF-12) questionnaire. Associations of WML progression with changes in functioning were adjusted for age, sex, and vascular risk factors. Results. Physical functioning (baseline: 44, 10th-90th percentile 29-55) improved, whereas mental functioning (baseline: 51, 10th-90th percentile 32-60) declined during followup. WML progression (highest quartile versus rest) contributed to a stronger decline in mental functioning (B = -1.76, 95% CI -3.11 to -0.42), but did not influence changes in physical functioning. Conclusions. Progression of WML volume contributes to a decline in mental functioning in patients with symptomatic atherosclerotic disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean changes in physical and mental functioning for different locations of symptomatic atherosclerotic disease, adjusted for age, sex, baseline functioning, and follow-up time. Significant differences, compared to other locations of symptomatic atherosclerotic disease, are indicated with an asterix.
Figure 2
Figure 2
Mean changes in physical and mental functioning for patients with greatest progression of white matter lesion (WML) volume (highest quartile, >0.07% increase in WML volume as % of ICV) versus patients in the lower three quartiles of progression, adjusted for age, sex, baseline functioning, and follow-up time. Significant differences are indicated with an asterix.
Figure 3
Figure 3
Mean changes in mental functioning for patients with greatest progression of white matter lesion (WML) volume versus patients in the lower three quartiles of progression, for different locations of symptomatic atherosclerotic disease, adjusted for age, sex, baseline functioning, and follow-up time. Significant differences are indicated with an asterix.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002–2030. Annals of Tropical Medicine and Parasitology. 2006;100(5-6):481–499. - PubMed
    1. Idler EL, Benyamini Y. Self-rated health and mortality: a review of twenty-seven community studies. Journal of Health and Social Behavior. 1997;38(1):21–37. - PubMed
    1. Myint PK, Luben RN, Surtees PG, et al. Self-reported mental health-related quality of life and mortality in men and women in the European Prospective Investigation into Cancer (EPIC-Norfolk): a prospective population study. Psychosomatic Medicine. 2007;69(5):410–414. - PubMed
    1. Myint PK, Surtees PG, Wainwright NWJ, et al. Physical health-related quality of life predicts stroke in the EPIC-Norfolk. Neurology. 2007;69(24):2243–2248. - PubMed
    1. Xie J, Wu EQ, Zheng ZJ, Sullivan PW, Zhan L, Labarthe DR. Patient-reported health status in coronary heart disease in the United States: age, sex, racial, and ethnic differences. Circulation. 2008;118(5):491–497. - PubMed

LinkOut - more resources