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Comment
. 2012 Apr;165(8):2411-3.
doi: 10.1111/j.1476-5381.2011.01731.x.

So what do we call GPR18 now?

S P H Alexander  1
Affiliations
Comment

So what do we call GPR18 now?

S P H Alexander. Br J Pharmacol. 2012 Apr.

Abstract

The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a pharmacological profile that raises some interesting questions about the nomenclature of this receptor and may also prompt some questions about the pharmacological definition of the classical cannabinoid receptors, CB(1) and CB(2) . LINKED ARTICLES This article is a commentary on McHugh et al., pp. 2414-2424 of this issue and is part of a themed section on Cannabinoids in Biology and Medicine. To view McHugh et al. visit http://dx.doi.org/10.1111/j.1476-5381.2011.01497.x. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-8. To view Part I of Cannabinoids in Biology and Medicine visit http://dx.doi.org/10.1111/bph.2011.163.issue-7.

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Figures

Figure 1
Figure 1
An evaluation of GPR18 pharmacology (A) and structure (B). The structures shown in (A) are of AEA, an endogenous cannabinoid; NAGly, the putative endogenous agonist for GPR18 receptors; and Δ9-THC, the archetypal natural cannabinoid from the Cannabis plant. An unrooted dendrogram in (B) illustrates sequence similarities for putative cannabinoid and cannabinoid-like receptors in man (conducted using ClustalX2).
See this image and copyright information in PMC

Comment on

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