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. 2011 Oct 20:9:134.
doi: 10.1186/1477-7819-9-134.

Retrospective analysis for thirty-nine patients with solitary fibrous tumor of pleura and review of the literature

Wei Guo  1 , Hua-Liang Xiao, Yao-Guang Jiang, Ru-Wen Wang, Yun-Ping Zhao, Zheng Ma, Hui-Jun Niu
Affiliations

Retrospective analysis for thirty-nine patients with solitary fibrous tumor of pleura and review of the literature

Wei Guo et al. World J Surg Oncol. .

Abstract

Background: Solitary fibrous tumor of the pleura (SFTP) is an uncommon neoplasm arising from mesenchymal cells. The aim of this study is to summarize the experience and the outcome of the surgical treatment for 39 cases of SFTP.

Methods: From January 2004 to December 2008, 39 patients underwent surgical resection of SFTP in our department. All patients had clinical follow-up by the same team of surgeons. The mean follow-up was 40.3 months.

Results: A local removal of the neoplasm was accomplished by video-assisted thoracic surgery (VATS) in 9 patients (group A) and by thoracotomy in 30 patients (group B) respectively. Comparing with group B, operations in group A took significantly less operative time, blood loss and spent less time in the intensive care unit and hospital. All specimens were positive for CD34 and Bcl-2. One patient developed recurrence, and the remaining 38 patients are alive and disease free at the end of follow-up.

Conclusions: Malignant SFTP still had the potential recurrence. VATS represents the more acceptable choice for the selected patients with SFTP.

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Figures

Figure 1
Figure 1
Gradually increasing tendency of SFTPs. (A) During the 5 years from 2004 to 2008, the cases with pathological diagnosis of SFTP in our hospital were observed gradually increased. (B) Comparing to the simultaneous total number of operations, the ratio is also in increasing.
Figure 2
Figure 2
Enhancement of SFTP showed by chest CT scans. (A, B) Before the injection of contrast agent. (C, D) Partial enhancement of SFTP after injection.
Figure 3
Figure 3
Immunohistochemical staining of the SFTPs. (A) Positive staining of CD34 was observed especially in the vascular endothelial cells and tumor cells (200). (B) Positive staining for CD34 in a malignant SFTP (200). (C) Strong positive expression of Bcl-2 was observed in the cytoplasm of tumor cells (200). (D) Positive staining of Bcl-2 in a malignant SFTP (200). (E) Ki-67 LI is about 5% in a benign SFTP (200). (F) A malignant case in which the Ki-67 LI is about 15% (200).
Figure 4
Figure 4
Recurrence of SFTP in a case. (A) CT scan showed a prevalent intrapulmonary growth (the so-called inverted fibroma). (B) Another smoothly marginated abnormal mass occurred at right thorax with pleural effusion 6 months after surgery.
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