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Controlled Clinical Trial
. 2011 Oct 21:9:140.
doi: 10.1186/1477-7827-9-140.

Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures

Shang Yu Huang  1 , Chin-Jung Wang, Yung-Kuei Soong, Hsin-Shih Wang, Mei Li Wang, Chieh Yu Lin, Chia Lin Chang
Affiliations
Controlled Clinical Trial

Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures

Shang Yu Huang et al. Reprod Biol Endocrinol. .

Abstract

Background: To test whether a site-specific hysteroscopic biopsy-induced injury in the endometrium during the controlled ovarian hyperstimulation cycle improves subsequent embryo implantation in patients with repeated implantation failure, a total of 30 patients who have had good responses to controlled ovulation stimulation but have failed to achieve pregnancy after two or more transfers of good-quality embryos were recruited in this prospective study.

Methods: A single, site-specific hysteroscopic biopsy-induced injury was generated on the posterior endometrium at midline 10-15 mm from the fundus during the D4-D7 period of the ongoing controlled ovarian hyperstimulation cycle in six patients.

Results: Patients received endometrial biopsy protocol achieved a pregnancy rate of 100%. By contrast, only 46% of patients with similar clinical characteristics (N = 24) achieved pregnancy without the hysteroscopic biopsy-induced endometrium injury (p < 0.05).

Conclusions: Our proof-of-concept study demonstrates that a site-specific hysteroscopic endometrium injury performed during the ongoing in vitro fertilization (IVF) cycle, instead of injuries received during prior cycles, significantly improves clinical outcomes in patients with repeated implantation failure.

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Figures

Figure 1
Figure 1
Image of an operation during which an injury in the endometrium was generated using a flexible hysterofibrescope. The injured site is indicated by an arrow.
See this image and copyright information in PMC

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