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Comment
. 2011 Oct 18;20(4):415-6.
doi: 10.1016/j.ccr.2011.10.003.

Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis

Angela Bowman  1 , Roel Nusse
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Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis

Angela Bowman et al. Cancer Cell. .
Free article

Abstract

Genetic alterations in the Wnt/β-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates β-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/β-catenin pathway activation.

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