Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Nov 15;19(22):6599-603.
doi: 10.1016/j.bmc.2011.09.026. Epub 2011 Sep 21.

Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima

Priscilla L Winder  1 , Heather L Baker, Patricia Linley, Esther A Guzmán, Shirley A Pomponi, M Cristina Diaz, John K Reed, Amy E Wright
Affiliations

Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima

Priscilla L Winder et al. Bioorg Med Chem. .

Abstract

Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC(50) values of 3.7 and 9.8 μM, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC(50) values of 6.1 and 13.8 μM, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC(50) value of 6.1 μM. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Lepourcelet M, Chen YN, France DS, Wang H, Crews P, Petersen F, Bruseo C, Wood AW, Shivdasani RA. Cancer Cell. 2004;5:91. - PubMed
    1. van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H. Cell. 2002;111:241. - PubMed
    1. Pretsch E, Clerc T, Seibl J, Simon W. Tables of Spectral Data for Structure Determination of Organic Compounds: 13C-NMR, 1H-NMR, IR, MS, UV/VIS Chemical Laboratory Practice. Springer-Verlag; 1983.
    1. Rodrigues S, Viana L, Baumann W. Analytical and Bioanalytical Chemistry. 2006;385:895. - PubMed
    1. Kurata K, Taniguchi K, Suzuki M. Phytochemistry. 1996;41:749.

Publication types

LinkOut - more resources