Comment on

• Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

  Tissenbaum HA, Guarente L. Tissenbaum HA, et al. Nature. 2001 Mar 8;410(6825):227-30. doi: 10.1038/35065638. Nature. 2001. PMID: 11242085
• Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes.

  Viswanathan M, Guarente L. Viswanathan M, et al. Nature. 2011 Sep 21;477(7365):E1-2. doi: 10.1038/nature10440. Nature. 2011. PMID: 21938026 No abstract available.
• Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

  Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D. Burnett C, et al. Nature. 2011 Sep 21;477(7365):482-5. doi: 10.1038/nature10296. Nature. 2011. PMID: 21938067 Free PMC article.