Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Sep 1;172(3):911-9.
doi: 10.1084/jem.172.3.911.

Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues

P Tekamp-Olson  1 , C Gallegos, D Bauer, J McClain, B Sherry, M Fabre, S van Deventer, A Cerami
Affiliations
Comparative Study

Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues

P Tekamp-Olson et al. J Exp Med. .

Abstract

A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2 from a library prepared from phorbol myristate acetate-treated and LPS-stimulated U937 cells. Two homologues were isolated and sequenced. Human MIP-2 alpha and MIP-2 beta are highly homologous to each other and to a previously isolated gene, human gro/melanoma growth-stimulating activity (MGSA). These three human genes, MIP-2 alpha, MIP-2 beta, and gro/MGSA, constitute a sub-family within the cytokine family represented by platelet factor 4 and interleukin 8.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1977 Sep 25;252(18):6276-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6715-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7188-92 - PubMed
    1. J Immunol. 1987 Nov 15;139(10):3474-83 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9233-7 - PubMed

Publication types

Associated data