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. 1990 Sep;10(9):4990-5.
doi: 10.1128/mcb.10.9.4990-4995.1990.

A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter

N F Lowndes  1 , P Bushel, L Mendelsohn, J Wu, M Y Yen, M Allan
Affiliations

A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter

N F Lowndes et al. Mol Cell Biol. 1990 Sep.

Abstract

We have identified a short, highly repetitive element within intron -1 of the human c-Ha-ras gene. This element was found to be transcribed in both orientations and to be homologous to heterogeneous nonpolyadenylated transcripts. The repetitive element blocked transcriptional readthrough from a strong upstream viral promoter but allowed unimpaired readthrough from the c-Has-ras promoter. We suggest that it may serve to prevent excessive transcription into the coding region of the gene under such circumstances as viral insertion.

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