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. 1990 Aug 23;346(6286):719-23.
doi: 10.1038/346719a0.

Stimulation of p21ras upon T-cell activation

J Downward  1 , J D Graves, P H Warne, S Rayter, D A Cantrell
Affiliations

Stimulation of p21ras upon T-cell activation

J Downward et al. Nature. .

Abstract

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

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