doi: 10.1038/346719a0.
Stimulation of p21ras upon T-cell activation
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- PMID: 2201921
- DOI: 10.1038/346719a0
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Stimulation of p21ras upon T-cell activation
Nature.
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Abstract
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
Comment in
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Oncoproteins. GAPs in understanding Ras.Nature. 1990 Aug 23;346(6286):696-7. doi: 10.1038/346696a0. Nature. 1990. PMID: 2201920 No abstract available.
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