Review
doi: 10.1016/0168-9525(90)90182-6.
Human globin locus activation region (LAR): role in temporal control
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- PMID: 2202110
- DOI: 10.1016/0168-9525(90)90182-6
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Review
Human globin locus activation region (LAR): role in temporal control
Trends Genet.
1990 Jul.
Abstract
A region of DNA located far upstream of the human beta-globin locus is critically involved in the regulation of the beta-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.
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