Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1990 Jul;6(7):219-23.
doi: 10.1016/0168-9525(90)90182-6.

Human globin locus activation region (LAR): role in temporal control

T M Townes  1 , R R Behringer
Affiliations
Review

Human globin locus activation region (LAR): role in temporal control

T M Townes et al. Trends Genet. 1990 Jul.

Abstract

A region of DNA located far upstream of the human beta-globin locus is critically involved in the regulation of the beta-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.

PubMed Disclaimer

LinkOut - more resources