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. 2011 Sep;43(5):586-90.
doi: 10.4103/0253-7613.84978.

Evaluation of anti-ulcer activity of Samanea saman (Jacq) merr bark on ethanol and stress induced gastric lesions in albino rats

Suresh Arumugam  1 , Senthil Velan Selvaraj, Suresh Velayutham, Senthil Kumar Natesan, Karthikeyan Palaniswamy
Affiliations

Evaluation of anti-ulcer activity of Samanea saman (Jacq) merr bark on ethanol and stress induced gastric lesions in albino rats

Suresh Arumugam et al. Indian J Pharmacol. 2011 Sep.

Abstract

Objective: To evaluate the antiulcer activity of Samanea saman (Jacq) Merr bark on ethanol and stress induced gastric lesions in albino rats.

Materials and methods: Gastric lesions were induced in rats by oral administration of absolute ethanol (5 ml/kg) and stress induced by water immersion. The antiulcer activity of methanolic extract of Samanea saman (Jacq) Merr bark (100 mg/kg, 200 mg/kg, 400 mg/kg) was compared with standard drugs. The parameters studied were ulcer index, gastric juice volume, pH, free acidity and total acidity.

Result: Samanea saman (Jacq) Merr showed a dose dependent curative ratio compared to ulcer control groups. The extract at 400 mg/kg showed significant anti ulcer activity which is almost equal to that of the standard drug in both models. The volume of acid secretion, total and free acidity was decreased and pH of the gastric juice was increased compared to ulcer control group.

Conclusions: The present study indicates that Samanea saman (Jacq) Merr bark extracts have potential anti ulcer activity.

Keywords: Ethanol induced ulcer; Samanea saman (Jacq) Merr; Stress induced ulcer; Ulcer index.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Effect of Samanea saman (Jacq) Merr on ethanol induced ulcers in the rats in the study (a) Normal Control (b) Ulcer Control (c) S. saman (100 mg/kg) treated (d) S. saman (200 mg/kg) treated (e) S. saman (400 mg/kg) treated (f) Sucralfate (100 mg/kg) treated
Figure 2
Figure 2
Effect of Samanea saman (Jacq) Merr on stress induced ulcers in the rats in the study (a) Normal Control (b) Ulcer Control (c) S. saman (100 mg/kg) treated (d) S. saman (200 mg/kg) treated (e) S. saman (400 mg/kg) treated (f) Omeprazole (20 mg/kg treated)
See this image and copyright information in PMC

References

    1. Akhtar AH, Ahmad KU. Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin ulcerated rats. J Ethnopharmacol. 1995;46:1–6. - PubMed
    1. Hoogerwerf WA, Pasricha PJ. Agents used for the control of gastric acidity and treatment of peptic ulcers and gastro oesophageal refl ux diseases. In: Hardman JG, Limbrid LE, Goodman CS, Gilman BT, editors. Goodman and Gilman's. The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill; 2001. pp. 1005–19.
    1. Bandyopadhyay U, Biswas K, Chatterjee R, Bandyopadhyay D, Chattopadhyay I, Ganguly CK, et al. Gastroprotective effect of Neem (Azadiracta indica) bark extract possible involvement of H+K+ ATPase inhibition and scavenging of hydroxyl radical. Life Sci. 2002;71:2845–65. - PubMed
    1. Rajkapoor B, Anandan R, Jayakas B. Anti-ulcer effect of Nigella saliva Linn. against gastric lesions in rats. Curr Sci. 2002;82:177–9.
    1. Mozafar Khazaei, Hossein salehi. Protective effect of Falcaria vulgaris on ethanol induced gastric lesion in rats. Indian J Pharmacol Therapeutics. 2006;5:43–6.