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Review
. 2011;8(7):635-9.
doi: 10.7150/ijms.8.635. Epub 2011 Oct 14.

Multiple Aspergillus cerebellar abscesses in a middle-aged female: case report and literature review

Sheng Chen  1 , Jia-Li Pu, Jun Yu, Jian-Min Zhang
Affiliations
Review

Multiple Aspergillus cerebellar abscesses in a middle-aged female: case report and literature review

Sheng Chen et al. Int J Med Sci. 2011.

Abstract

Aspergillus abscesses in the cerebellum are extremely rare, and most cases are solitary. Here, we report the first case of multiple Aspergillus cerebellar abscesses in a 46-year-old female after one mastoidectomy, two craniectomies, and extended use of antibiotics. The possible pathogenesis of this unusual event is discussed. Good outcome was achieved by treatment with a combination of neurosurgical resection and voriconazole (VRC) administration, which we suggest is a potential management plan.

Keywords: Aspergillus; Cerebellum; Neurosurgical resection; Voriconazole.

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Conflict of interest statement

Conflict of Interest: The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Enhanced MRI and CT of the brain through the entire course of the illness. (A) and (B) Enhanced MRI showing a ring-enhancing lesion in the right cerebellum suggesting an otogenic pyogenic abscess (arrowhead). (G), (H) and (I) Enhanced MRI showing multiple oval-shaped contrast-enhanced lesions (arrow) with irregular thick peripheral enhancement which were hypointense in T1-weighted images and hyperintense in T2-weighted images and which occupied the right cerebellum.
Figure 2
Figure 2
Histopathology photomicrograph. The cerebellar lesion shows the typical branching septate hyphae of Aspergillus.
Figure 3
Figure 3
Time-course of the entire illness.
See this image and copyright information in PMC

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