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. 2011 Oct;7(10):e1002165.
doi: 10.1371/journal.ppat.1002165. Epub 2011 Oct 13.

Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm

Siddharth Balachandran  1 , Amer A Beg
Affiliations

Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm

Siddharth Balachandran et al. PLoS Pathog. 2011 Oct.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Temporally distinct roles for NF-κB in antivirus innate immune responses.
(A) In uninfected cells, NF-κB cycles robustly through the nucleus to maintain constitutive expression of basal ifnβ and sustain sutocrine IFN-β signaling. (B) Early in an infection, NF-κB cooperates with ATF-2/c-Jun and IRF-3 to recruit the transcription co-activator CBP/p300 to the ifnβ enhancer. (C) Later in an infection, IRF-3/7 powers expression of ifnβ, and NF-κB is rendered redundant in the ifnβ enhanceosome. (D) NF-κB then switches to regulating a distinct subset of non-IFN genes, including those involved in inflammation and cell survival. The relative importance of each transcription factor in driving gene expression during a particular stage of the immune response is indicated by the intensity of its color, with darker shades representing essential functions, and lighter shades indicating reduced roles.
See this image and copyright information in PMC

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