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Comparative Study
. 2011 Nov;19(11):932-9.
doi: 10.1097/JGP.0b013e318209dd3a.

Practice effects predict cognitive outcome in amnestic mild cognitive impairment

Kevin Duff  1 , Constantine G Lyketsos, Leigh J Beglinger, Gordon Chelune, David J Moser, Stephan Arndt, Susan K Schultz, Jane S Paulsen, Ronald C Petersen, Robert J McCaffrey
Affiliations
Comparative Study

Practice effects predict cognitive outcome in amnestic mild cognitive impairment

Kevin Duff et al. Am J Geriatr Psychiatry. 2011 Nov.

Abstract

Objective: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI.

Design: Longitudinal, observational design following participants across 1 year.

Setting: Community-based cohort.

Participants: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26).

Measurements: Neuropsychological tests.

Results: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition.

Conclusions: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.

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Figures

Figure 1
Figure 1
Cognitive trajectories on RBANS Delayed Memory Index across one year in three groups Y-axis is age-corrected standard scores (M=100, SD=15) on the RBANS Delayed Memory Index. Baseline and One Year scores based on estimated marginal means from ANCOVA controlling for age and baseline score. MCI+PE = participants with amnestic Mild Cognitive Impairment with large practice effects across one week. MCI−PE = participants with amnestic Mild Cognitive Impairment with minimal practice effects across one week.
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References

    1. McCaffrey RJ, Duff K, Westervelt HJ. Practitioner’s Guide to Evaluating Change with Neuropsychological Assessment Instruments. New York: Plenum/Kluwer; 2000.
    1. Beglinger LJ, Gaydos B, Tangphao-Daniels O, et al. Practice effects and the use of alternate forms in serial neuropsychological testing. Arch Clin Neuropsychol. 2005;20:517–529. - PubMed
    1. Cooper DB, Epker M, Lacritz L, et al. Effects of practice on category fluency in Alzheimer’s disease. Clin Neuropsychol. 2001;15:125–128. - PubMed
    1. Helkala EL, Kivipelto M, Hallikainen M, et al. Usefulness of repeated presentation of Mini-Mental State Examination as a diagnostic procedure--a population-based study. Acta Neurol Scand. 2002;106:341–346. - PubMed
    1. Darby D, Maruff P, Collie A, et al. Mild cognitive impairment can be detected by multiple assessments in a single day. Neurology. 2002;59:1042–1046. - PubMed

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