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Comment
. 2011 Nov 1;10(21):3629-30.
doi: 10.4161/cc.10.21.18034. Epub 2011 Nov 1.

Neuroendocrine cells: potential cells of origin for small cell lung carcinoma

Chieh-Yang Cheng, Alexander Y Nikitin
Comment

Neuroendocrine cells: potential cells of origin for small cell lung carcinoma

Chieh-Yang Cheng et al. Cell Cycle. .
No abstract available

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Figures

Figure 1
Figure 1
Models of potential origin of SCLC. Model 1 proposes that unipotent stem/progenitor cells or mature cells of neuroendocrine cell lineage give rise to SCLC. This model anticipates that cells lacking p53 and Rb may differentiate toward other types of lung cancer, such as adenocarcinoma and squamous cell carcinoma in some cases. Model 2 proposes that SCLC arises from stem/progenitor cells able to differentiate toward several cell types, including neuroendocrine cells. Model 3 suggests that at least some of SCLCs could arise from non-neuroendocrine cell lineages due to differentiation plasticity of cells deficient for p53 and Rb.
See this image and copyright information in PMC

Comment on

  • Characterization of the cell of origin for small cell lung cancer.
    Park KS, Liang MC, Raiser DM, Zamponi R, Roach RR, Curtis SJ, Walton Z, Schaffer BE, Roake CM, Zmoos AF, Kriegel C, Wong KK, Sage J, Kim CF. Park KS, et al. Cell Cycle. 2011 Aug 15;10(16):2806-15. doi: 10.4161/cc.10.16.17012. Epub 2011 Aug 15. Cell Cycle. 2011. PMID: 21822053 Free PMC article.

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