Tumour immunology: IFNs boost cancer killers

Comment

Olive Leavy. Nat Rev Immunol. 2011.

. 2011 Oct 25;11(11):718.

doi: 10.1038/nri3094.

No abstract available

Comment on

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Fuertes MB, Kacha AK, Kline J, Woo SR, Kranz DM, Murphy KM, Gajewski TF. Fuertes MB, et al. J Exp Med. 2011 Sep 26;208(10):2005-16. doi: 10.1084/jem.20101159. Epub 2011 Sep 19. J Exp Med. 2011. PMID: 21930765 Free PMC article.
Type I interferon is selectively required by dendritic cells for immune rejection of tumors.
Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, Lee H, Arthur CD, White JM, Kalinke U, Murphy KM, Schreiber RD. Diamond MS, et al. J Exp Med. 2011 Sep 26;208(10):1989-2003. doi: 10.1084/jem.20101158. Epub 2011 Sep 19. J Exp Med. 2011. PMID: 21930769 Free PMC article.