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. 2011 Oct 5;52(40):5128-5230.
doi: 10.1016/j.tetlet.2011.07.102.

Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales

Sloan Ayers  1 , Tyler N Graf, Audrey F Adcock, David J Kroll, Qi Shen, Steven M Swanson, Mansukh C Wani, Blaise A Darveaux, Cedric J Pearce, Nicholas H Oberlies
Affiliations

Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales

Sloan Ayers et al. Tetrahedron Lett. .

Abstract

A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested.

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Figures

Figure 1
Figure 1
Structures of obionin A (2) and obionin B (1)
Figure 2
Figure 2
HMBC correlations of obionin B (1)
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