Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Sep;111(3):1225-32.
doi: 10.1083/jcb.111.3.1225.

Direct demonstration of the lectin activity of gp90MEL, a lymphocyte homing receptor

Y Imai  1 , D D True, M S Singer, S D Rosen
Affiliations

Direct demonstration of the lectin activity of gp90MEL, a lymphocyte homing receptor

Y Imai et al. J Cell Biol. 1990 Sep.

Abstract

Considerable evidence implicates gp90MEL as a lymphocyte homing receptor mediating lymphocyte attachment to high endothelial venules of lymph nodes in mouse. The protein appears to function as a calcium-dependent, lectin-like receptor as inferred primarily by the ability of specific carbohydrates to block its function and by the presence of a calcium-type lectin domain in its primary sequence. An ELISA assay is described which provides the first demonstration that the isolated protein has lectin activity and allows a further definition of its carbohydrate specificity. In addition to the monosaccharides mannose-6-phosphate and fructose-1-phosphate, ligand activity is shown for the sulfated glycolipid, sulfatide, and for two sulfated fucose-containing polysaccharides (fucoidin and egg jelly coat) from nonmammalian sources.

PubMed Disclaimer

References

    1. Annu Rev Immunol. 1987;5:201-22 - PubMed
    1. J Cell Biol. 1990 Jun;110(6):2221-9 - PubMed
    1. J Cell Biol. 1987 Aug;105(2):991-7 - PubMed
    1. J Biol Chem. 1987 Oct 15;262(29):13946-52 - PubMed
    1. Blood. 1987 Dec;70(6):1842-50 - PubMed

Publication types