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. 2011 Jul;15(3):255-9.
doi: 10.4103/0972-124X.85670.

The effect of ketoprofen in chronic periodontitis: A clinical double-blind study

M Srinivas  1 , Sangeetha Medaiah, S Girish, M Anil, Jagadish Pai, Amit Walvekar
Affiliations

The effect of ketoprofen in chronic periodontitis: A clinical double-blind study

M Srinivas et al. J Indian Soc Periodontol. 2011 Jul.

Abstract

Background: The objective of this double-blind clinical trial was to evaluate the effects of the nonsteroidal anti-inflammatory drug (NSAID), ketoprofen, on patients with chronic periodontitis.

Materials and methods: Two similar local drug delivery preparations of a poloxamen gel containing 1.5% ketoprofen and a placebo were indigenously prepared for this purpose. Ten subjects aged 33-55 years with moderate to severe chronic periodontitis were recruited and were monitored for a period of 90 days. Three sites in each patient (total 30 sites) with a probing pocket depth of 5-8 mm were selected and divided randomly into three groups: 1) group A: scaling and rootplaning (SRP) + drug A; 2) group B: SRP + drug B; and 3) group C: SRP. Clinical parameters and blood smear (from intracrevicular blood) were assessed to determine the differential count and Arneth index. All parameters were assessed at baseline, 30 days and 90 days, respectively.

Results: Highly significant values were achieved for plaque index (P=0.00), and significant values were obtained for gingival index (P=0.044). Reduction in bleeding on probing was found to be highly significant. Probing depth and clinical attachment level showed no inter group variation.

Conclusion: The results of this double-blind trial indicate that the combined effect of locally delivered ketoprofen with SRP was more effective in controlling periodontal disease than SRP alone.

Keywords: Arneth index; bleeding on probing; ketoprofen gel; placebo.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Drug release pattern of ketoprofen
Figure 2
Figure 2
Placement of ketoprofen gel
Figure 3
Figure 3
Probing depth in group B (SRP + ketoprofen) at 30 days
Figure 4
Figure 4
Probing depth in group B at 90 days
Figure 5
Figure 5
Obtaining intracrevicular blood
Figure 6
Figure 6
Graphic representation of Arneth index
See this image and copyright information in PMC

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