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. 2012 Feb;43(1):117-28.
doi: 10.1007/s12160-011-9309-6.

Social and material adversity from adolescence to adulthood and allostatic load in middle-aged women and men: results from the Northern Swedish Cohort

Per E Gustafsson  1 , Urban Janlert, Töres Theorell, Hugo Westerlund, Anne Hammarström
Affiliations

Social and material adversity from adolescence to adulthood and allostatic load in middle-aged women and men: results from the Northern Swedish Cohort

Per E Gustafsson et al. Ann Behav Med. 2012 Feb.

Abstract

Background: Little is known about the theoretically assumed association between adversity exposure over the life course and allostatic load in adulthood.

Purpose: This study aims to examine whether social and material adversity over the life course is related to allostatic load in mid-adulthood.

Methods: A 27-year prospective Swedish cohort (N = 822; 77% response rate) reported exposure to social and material adversities at age 16, 21, 30 and 43 years. At age 43, allostatic load was operationalized based on 12 biological parameters.

Results: Social adversity accumulated over the life course was related to allostatic load in both women and men, independently of cumulative socioeconomic disadvantage. Moreover, social adversity in adolescence (in women) and young adulthood (in men) was related to allostatic load, independently of cumulative socioeconomic disadvantage and also of later adversity exposure during adulthood.

Conclusion: Exposure to adversities involving relational threats impacts on allostatic load in adulthood and operates according to life course models of cumulative risk and a sensitive period around the transition into adulthood.

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References

    1. McEwen BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998;338:171–179. doi: 10.1056/NEJM199801153380307. - DOI - PubMed
    1. Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. 2010;35:2–16. doi: 10.1016/j.neubiorev.2009.10.002. - DOI - PubMed
    1. Gersten O. The path traveled and the path ahead for the allostatic framework: A rejoinder on the framework’s importance and the need for further work related to theory, data, and measurement. Soc Sci Med. 2008;66:531–535. doi: 10.1016/j.socscimed.2007.09.017. - DOI
    1. Seeman T, Gruenewald T, Karlamangla A, et al. Modeling multisystem biological risk in young adults: The Coronary Artery Risk Development in Young Adults Study. Am J Hum Biol. 2010;22:463–472. doi: 10.1002/ajhb.21018. - DOI - PMC - PubMed
    1. Seeman T, McEwen BS, Rowe JW, Singer BH. Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proc Natl Acad Sci U S A. 2001;98:4770–4775. doi: 10.1073/pnas.081072698. - DOI - PMC - PubMed

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