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. 2012 Jan;3(1):28-9.
doi: 10.1039/c1fo10173k. Epub 2011 Oct 28.

Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

Seyed Fazel Nabavi  1 , Seyed Mohammad Nabavi, Akbar Hajizadeh Moghaddam, Alireza Naqinezhad, Rata Bigdellou, Sakineh Mohammadzadeh
Affiliations

Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

Seyed Fazel Nabavi et al. Food Funct. 2012 Jan.

Abstract

Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg(-1) day(-1) offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg(-1) day(-1) has better activity than aerial parts.

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