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Comment
. 2011 Oct 28;334(6055):459-60.
doi: 10.1126/science.1214057.

Cancer. BRCA1, everything but the RING?

Roger A Greenberg  1
Affiliations
Comment

Cancer. BRCA1, everything but the RING?

Roger A Greenberg. Science. .

Abstract

Genetically engineered mouse models reveal essential functions of the BRCA1 protein in tumor suppression.

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Figures

None
Functional ends. Amino-terminal BRCA1 E3 ubiquitin ligase activity is not required for tumor suppression or DNA repair, in contrast to the BRCA1 carboxyl-terminal phosphoprotein binding domain.
See this image and copyright information in PMC

Comment on

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