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. 2011 Apr-Jun;1(2):182-91.
doi: 10.4103/2045-8932.83455.

Lung transplantation for pulmonary hypertension

M Patricia George  1 , Hunter C Champion, Joseph M Pilewski
Affiliations

Lung transplantation for pulmonary hypertension

M Patricia George et al. Pulm Circ. 2011 Apr-Jun.

Abstract

Although medical therapies for pulmonary arterial hypertension have greatly improved, it remains a chronic and fatal disease. For patients who are refractory to medical therapy, lung transplantation is an important treatment option. This review discusses issues pertaining to indications for transplant, preparation for transplant and listing, operative issues, and outcomes for patients with pulmonary arterial hypertension.

Keywords: lung transplant; outcome; pulmonary arterial hypertension; surgical treatment.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Since the first lung transplant in 1986, the number of lung transplants continues to grow.[7]
Figure 2
Figure 2
Timeline of major medical and surgical developments in the treatment of pulmonary arterial hypertension.
Figure 3
Figure 3
Double lung transplantation is an effective treatment for PAH. Chest radiographs (a) pre- and (b) post-double lung transplant demonstrate radiographic resolution of enlarged pulmonary arteries and right ventricular remodeling post transplant. Echocardiographic images (c) pre- and (d) post-transplant demonstrate resolution of right atrial enlargement and septal bowing seen in severe PAH.
See this image and copyright information in PMC

References

    1. Dresdale DT, Schultz M, Michtom RJ. Primary pulmonary hypertension. I. Primary pulmonary hypertension I Clinical and hemodynamic study. Am J Med. 1951;11:686–705. - PubMed
    1. D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med. 1991;115:343–9. - PubMed
    1. Reitz BA. The first successful combined heart-lung transplantation. J Thorac Cardiovasc Surg. 2011;141:867–9. - PubMed
    1. Cooper JD, Pearson FG, Patterson GA, Todd TR, Ginsberg RJ, Goldberg M, et al. Technique of successful lung transplantation in humans. ;93:173-81. J Thorac Cardiovasc Surg. 1987;93:173–81. - PubMed
    1. Patterson GA, Cooper JD, Goldman B, Weisel RD, Pearson FG, Waters PF, et al. Technique of successful clinical double-lung transplantation. Ann Thorac Surg. 1988;45:626–33. - PubMed

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