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Randomized Controlled Trial
. 2012 May;27(5):695-702.
doi: 10.1016/j.arth.2011.09.014. Epub 2011 Oct 27.

Prospective randomized evaluation of a collagen/thrombin and autologous platelet hemostatic agent during total knee arthroplasty

Michael R Bloomfield  1 , Alison K Klika, Robert M Molloy, Mark I Froimson, Viktor E Krebs, Wael K Barsoum
Affiliations
Randomized Controlled Trial

Prospective randomized evaluation of a collagen/thrombin and autologous platelet hemostatic agent during total knee arthroplasty

Michael R Bloomfield et al. J Arthroplasty. 2012 May.

Abstract

The purpose of this study was to evaluate the effectiveness of a collagen/thrombin and autologous platelet hemostatic agent in preventing blood loss during primary total knee arthroplasty. This prospective, double-blinded, randomized study was designed to enroll a total of 100 patients. Patients were randomized 1:1 to either the treatment arm (standard hemostasis plus study product) or the control arm (standard hemostasis alone). Transfusion requirements, as determined by a blinded investigator using standardized criteria, were significantly lower in the treatment group (no blood transfusions) compared with the control group (5 transfusions; P = .007). These data support the addition of the study product to prevent blood transfusions after primary total knee arthroplasty.

Trial registration: ClinicalTrials.gov NCT01027286.

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