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. 1979 Feb;110(2):421-9.
doi: 10.1099/00221287-110-2-421.

Phagolysosome formation, cyclic adenosine 3':5'-monophosphate and the fate of Salmonella typhimurium within mouse peritoneal macrophages

M E Carrol, P S Jackett, V R Aber, D B Lowrie

Phagolysosome formation, cyclic adenosine 3':5'-monophosphate and the fate of Salmonella typhimurium within mouse peritoneal macrophages

M E Carrol et al. J Gen Microbiol. 1979 Feb.

Abstract

Salmonella typhimurium did not inhibit fusion of lysosomes with the phagocytic vacuoles in infected macrophages and caused no increase in cyclic adenosine 3':5'-monophosphate. Glutaraldehyde-killed bacteria showed rapid ultrastructural degeneration within the phagolysosomes. In contrast, untreated bacteria were resistant to digestion by lysosomal enzymes. Intracellular survival of this species appears to depend on resistance to, and not evasion of, lysosomal enzymes.

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