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Review
. 2012 Mar;58(3):334-43.
doi: 10.1002/pbc.23385. Epub 2011 Oct 28.

Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies

Melissa M Hudson  1 , Joseph P Neglia, William G Woods, John T Sandlund, Ching-Hon Pui, Larry E Kun, Leslie L Robison, Daniel M Green
Affiliations
Review

Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies

Melissa M Hudson et al. Pediatr Blood Cancer. 2012 Mar.

Abstract

Investigations of long-term outcomes have been instrumental in designing safer and more effective contemporary therapies for pediatric hematological malignancies. Despite the significant therapeutic changes that have occurred over the last five decades, therapy modifications largely represent refinements of treatment protocols using agents and modalities that have been available for more than 30 years. This review summarizes major trends in the evolution of treatment of pediatric hematological malignancies since 1960 to support the relevance of the study of late effects of historical therapeutic approaches to the design and evaluation of contemporary treatment protocols and the follow-up of present-day survivors.

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Conflict of interest statement

Conflict of Interest: The authors have no conflict of interests to declare in regards to the content of this manuscript.

References

    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010 Sep-Oct;60(5):277–300. - PubMed
    1. Farber S, Diamond LK. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med. 1948 Jun 3;238(23):787–793. - PubMed
    1. Kersey JH. Fifty years of studies of the biology and therapy of childhood leukemia. Blood. 1997 Dec 1;90(11):4243–4251. - PubMed
    1. Pinkel D. Five-year follow-up of “total therapy” of childhood lymphocytic leukemia. JAMA. 1971 Apr 26;216(4):648–652. - PubMed
    1. Aur RJ, Simone JV, Hustu HO, Verzosa MS. A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia. Cancer. 1972 Feb;29(2):381–391. - PubMed

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