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. 2011 Oct;21(5):479-84.
doi: 10.1089/cap.2011.0009.

Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders

Benjamin I Goldstein  1 , Katelyn A Collinger, Francis Lotrich, Anna L Marsland, Mary-Kay Gill, David A Axelson, Boris Birmaher
Affiliations

Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders

Benjamin I Goldstein et al. J Child Adolesc Psychopharmacol. 2011 Oct.

Abstract

Mood symptoms in adult bipolar disorder are associated with increased proinflammatory markers and decreased brain-derived neurotrophic factor (BDNF). We examined serum interleukin-6, high-sensitivity C-reactive protein (hsCRP), and BDNF among 30 bipolar disorder adolescents. Hypomanic/manic symptoms were positively associated with hsCRP. BDNF levels were negatively associated with interleukin-6. Forty percent had cardiovascular high-risk hsCRP levels. Larger longitudinal studies are warranted.

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