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Comparative Study
. 2011 Oct;124(19):2993-6.

Therapeutic effects of endoscopic therapy combined with enteral nutrition on acute severe biliary pancreatitis

Wen-Ce Zhou  1 , Yu-Min Li, Hui Zhang, Xun Li, Lei Zhang, Wen-Bo Meng, Ke-Xiang Zhu, Quan-Bao Zhang, Min-Yan He
Affiliations
  • PMID: 22040542
Comparative Study

Therapeutic effects of endoscopic therapy combined with enteral nutrition on acute severe biliary pancreatitis

Wen-Ce Zhou et al. Chin Med J (Engl). 2011 Oct.

Abstract

Background: Acute severe biliary pancreatitis (ASBP) is a severe and fatal disease, and the expenditure is huge and therapeutic effects are still not satisfactory. This study aimed to improve the therapeutic effects and reduce the expenditure of ASBP treatment.

Methods: One hundred and five patients diagnosed with ASBP were referred to our department from January 2004 to July 2009. Diagnosis was based on the 2007 criteria of the Chinese Society of Surgery. Patients were divided into two groups; the E group: 50 patients who underwent endoscopic retrograde choledochopancreatography (ERCP) + endoscopic sphincterotomy (EST) + endoscopic lithotripsy basket (ESR) + endoscopic retrograde biliary drainage (ERBD) and enteral nutrition (EN), and the R group: 55 patients who underwent traditional treatment without ERCP. Subsequently, subjective symptoms, signs, biochemical analysis, serum endotoxin, tumor necrosis factor a, grades by computed tomography (CT), cost of hospitalization and length of stay were compared between the two groups.

Results: All enrolled patients complied well with all therapeutic regimens. Endoscopic therapy that combined EN could significantly improve symptoms, clinical signs, laboratory values, tumor necrosis factor a and endotoxin while significantly reducing hospital expenditure and length of hospital stay. The experimental findings revealed that there were obvious advantages in the E group compared with the R group.

Conclusions: Endoscopic therapy combined with EN is an effective, safe and economic therapeutic regimen of ASBP.

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